Synthesis of glycine ethyl ester hydrochloride - …

Hydrolysis of the analytically pure benzyl ester monoacids afforded clean products as the diacids.
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Get Amino Acid Benzyl Esters at Spectrum Chemical

Groups of 12 Wistar rats of each sex were fed a powdered mixture of butyl--hydroxybenzoate and dog chow providing a dose of 0, 2000, or 8000 mg/kg bw per day for 12 weeks. Body weight and food intake were measured every 2 weeks, and necropsy and histological examinations were performed at the end of the experiment. Animals found dead before the end of the study were necropsied and the appropriate tissues were fixed for histopathological evaluation. Although there were no effects at the low dose, all the males and many of the females at the high dose died within several weeks of the beginning of treatment. The body weights and motor activity of these animals were decreased, and they had a slower growth rate than controls. The NOEL was 2000 mg/kg bw per day (Matthews et al., 1956).

Flavouring agentBenzyl acetate is an organic compound with the molecular formula C9H10O2.
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Synthesis Of Amino Acids Esters And Their Derivatives

Efficient synthesis of amides directly from esters and amines is achieved under mild, neutral conditions with the liberation of molecular hydrogen. Both primary and secondary amines can be utilized. This unprecedented, general, environmentally benign reaction is homogeneously catalyzed under neutral conditions by a dearomatized ruthenium−pincer PNN complex and proceeds in toluene under an inert atmosphere with a high turnover number (up to 1000). PNP analogues do not catalyze this transformation, underlining the crucial importance of the amine arm of the pincer ligand. A mechanism is proposed involving metal−ligand cooperation via aromatization−dearomatization of the pyridine moiety and hemilability of the amine arm.

Glycine ethyl ester hydrochloride was prepared from the N-benzyl glycine ethyl ester hydrochloride.
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The Committee evaluated a group of flavouring agents comprising 46 structurally related substances using the Procedure for the Safety Evaluation of Flavouring Agents (see Figure 1, Introduction). All members of this group are aromatic primary alcohols, aldehydes, carboxylic acids, or their corresponding esters or acetals. The structural feature common to all members of the group is a primary oxygenated functional group bound directly to a benzene ring. The ring also contains hydroxy or alkoxy substituents (see Table 1).

In the industrial odors, the volatility of Benzyl-acetate is often only an advantage.”
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Glycine benzyl ester hydrochloride_CAS#:1738-68 …

It is the ester formed by condensation of benzyl alcohol and acetic acid.; It is one of many compounds that is attractive to males of various species of orchid bees, who apparently gather the chemical to synthesize pheromones; it is commonly used as bait to attract and collect these bees for study.


Glycine ethyl ester hydrochloride in alkaline conditions with benzyl chloride by the reaction of N-benzyl glycine ethyl ester, and then treated with HCl gas is obtained N-benzyl glycine ethyl ester hydrochloride.

Synthesis description for preparation of GLYCINE (AMINOACETIC ACID)

The aromatic esters in this group are expected to be appreciably hydrolysed through the catalytic activity of the intestinal carboxylesterases, especially -esterases, to benzyl alcohol or benzoic acid derivatives before absorption (Heymann, 1980; Anders, 1989). Likewise, acetals of substituted benzaldehyde derivatives are hydrolysed in gastric and intestinal fluids to yield benzaldehyde and component aliphatic alcohols. The resulting hydroxy- and alkoxy-substituted benzyl derivatives are rapidly absorbed in the gut, metabolized in the liver, and excreted in urine (Davison, 1971; Abdo et al., 1985; Temellini et al., 1993).

N-(diphenylmethylene) Glycine benzyl ester (CAS …

These esters are stored as stable hydrochloride salts and were used in the synthesis of peptide nucleic acid monomers possessing bis--Boc-protected nucleobase moieties on the exocyclic amino groups of ethyl cytosin-1-ylacetate, ethyl adenin-9-ylacetate and ethyl (6-benzylguanin-9-yl)acetate.

N-(diphenylmethylene) Glycine benzyl ester

Amino acid esters refer to those derivatives of amino acids in which the carboxylic acid group is converted to an ester. Amino acid esters are employed as intermediates in organic synthesis and find application in a wide-range of areas such as medicinal chemistry, peptide synthesis, asymmetric synthesis, and polymer chemistry.

Amino acid esters are versatile chiral auxiliary groups that are employed for the asymmetric synthesis of pharmaceutically important nitrogen heterocycles. They are also useful as precursors for the synthesis of chiral amino alcohols which find application among other things as chiral catalysts or in the preparation of chiral auxiliaries for asymmetric transformations. Amino acid esters find use in pharmaceuticals as anticancer agent and antiviral drugs. Amino acid esters are employed as prodrugs to increase oral bioavailability in pharmaceuticals, for example, in certain antiviral nucleoside drugs. Amino acid esters are incorporated as specific side groups in order to make biostable polyphosphazenes, which are biodegradable. Some of the most widely studied synthetic degradable polyelectrolytes that find use in a number of biological applications, ranging from biomedical implant coatings and immunostimulants to vehicles for drug and nucleic acid delivery, are based on polyphosphazene and poly(beta-amino ester) scaffolds.