What steps in protein synthesis ..
Tetracycline Hydrochloride mode of action is as a protein synthesis inhibitor via an aminoacyl-tRNA binding mechanism to the 30S subunit. Mode of resistance is the loss of cell wall permeability.
Note, Tetracycline can lower red blood cell count and cause anemia, because of this I would not use with injured fish, as this is the last thing you want to do with a bleeding fish.
Antibiotics That Inhibit Protein Synthesis | SpringerLink
Bacitracin is a polypeptide antibiotic produced by Bacillus species. It prevents cell wall growth by inhibiting the release of the muropeptide subunits of peptidoglycan from the lipid carrier molecule that carries the subunit to the outside of the membrane Teichoic acid synthesis, which requires the same carrier, is also inhibited. Bacitracin has a high toxicity which precludes its systemic use. It is present in many topical antibiotic preparations, and since it is not absorbed by the gut, it is given to "sterilize" the bowel prior to surgery.
Tetracycline Hydrochloride is a naturally occurring Tetracycline used in the treatment of bacterial infections that are generally gram-positive such as Streptococcus and SOME gram-negative infections in fish.
It interferes with the production of proteins that the bacteria need to multiply and divide (bacteriostatic). However many bacterial pathogens have developed resistance to Tetracycline Hydrochloride.
inhibits the protein synthesis of bacteria?
Kanamycin and tobramycin have been reported to bindto the ribosomal 30S subunit and to prevent it from joining to the 50Ssubunitduring protein synthesis. They may have a bactericidal effect becausethisleads to cytoplasmic accumulation of dissociated 30S subunits, which isapparently lethal to the cells.
EFFECT OF ANTIBIOTICS AND INHIBITORS ON M PROTEIN SYNTHESIS.
Figure 2. A) Sites of action of inhibitors of bacterial protein synthesis. B) Macrolide antibiotics share a common macrocyclic lactone ring structure & deoxy sugar residues. The structures for erythromycin & clarithromycin differ only at one position (circled in green). Structures reproduced from .
Effect of antibiotics and inhibitors on M protein synthesis
This Concept Map, created with IHMC CmapTools, has information related to: Answers_Antibiotic_Modeofaction, macrolides action prevents peptidyltransferase from forming peptide bonds, inhibit synthesis of acid-fast cell walls examples ethambutol, antibiotic/chemical agent inhibits normal nucleic acid replication examples fluoroquinolones, puts nicks in the DNA strands of certain bacteria result blocks the replication of bacterial DNA, binds to 50S ribosomal subunit examples streptogramins, prevents peptidyltransferase from forming peptide bonds ????
50s_protein_synthesis_inhibitors [TUSOM | Pharmwiki]
inhibits elongation of the protein, antibiotic/chemical agent inhibits normal nucleic acid replication examples metronidazole, binds to 30S ribosomal subunit examples tetracyclines, no glycosidic or peptide bonds form; weak cell wall result osmotic lysis, antibiotics and chemical agents affect bacterial structures or functions.
50S Protein Synthesis Inhibitors
mode of action inhibit synthesis of acid-fast cell walls, inhibits elongation of the protein result blocks translation of mRNA into protein, binds to 50S ribosomal subunit examples oxazolidinones, binds to 30S ribosomal subunit examples aminoglycosides, bacitracin action binds to bactoprenol, interferes with the binding of the 50S subunit to the initiation complex result blocks translation of mRNA into protein, aminoglycosides action prevents the transfer of the peptidyl tRNA from the A-site to the P-site, fluoroquinolones action inhibits bacterial topoisomerase enzymes, antibiotic/chemical agent binds to prokaryotic ribosomal subunits ????