Carolina Heritage Builders | Ecgonine synthesis essay

Example 2 Synthesis of 2-Hydroxypropyl Ecgonine and 2 …
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RCW 69.50.101: Definitions. - Washington

We have also developed a simple synthetic route for preparing 2-hydroxypropylbenzoylecgonine. In that synthetic scheme, cocaine base is dissolved in propyleneglycol. No water is added. The solution is then heated at a temperature of about25°C to about 115°C until substantially all the cocaine has reacted and no additionalproduct forms (typically, approximately 4 days at 100°C). The propylene glycolis then removed using conventional means (such as vacuum distillation). The productcan then be purified using conventional techniques (such as recrystallization).

Lawriter - ORC - 3719.41 Controlled substance schedules.
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3719.41 Controlled substance schedules

We have developed a simple and convenient synthetic route which producesa mixture of benzoylecgonine, ecgonine and ecgonidine, and their 2-hydroxypropylderivatives (for simplicity, we will refer to this mixture as "the derivative mixture").We have found the derivative mixture to be especially well suited for the therapeuticapplications described herein. In the synthetic route, base cocaine is dissolvedin propylene glycol (about 5% base cocaine to about 90% propylene glycol, w/w)then about 5% water (w/w) is added. We then heat the solution at a temperatureof about 25°C to about 100°C until substantially all the cocaine has reacted andno additional product forms (typically, about an hour at 100°C or approximately12 days at 50°C). The reaction time can range from approximately one hour to approximatelythree weeks, depending on the exact reaction conditions used. We prefer to conductthe reaction at about 50°C for approximately 12 days.

Public Health Law Article 33 Section 3302 - Terms …
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Benzoylecgonine, ecgonine and ecgonidine are known metabolites ofcocaine (see, for example, S.M. Roberts et al., "An Assay for Cocaethylene andOther Cocaine Metabolites in Liver Using High-Performance Liquid Chromatography", Anal. Biochem., 202, pp. 256-61 (1992); D.T. Chia and J.A. Gere, "RapidDrug Screening Using Toxi-Lab Extraction Followed by Capillary Gas Chromatography/MassSpectroscopy", Clin. Biochem., 20, pp. 303-06 (1987)). Routes for theirpreparation have been established (see, for example, A.H. Lewin et al., "2β-SubstitutedAnalogues of Cocaine. Synthesis and Binding to the Cocaine Receptor", J. Med. Chem., 35, pp. 135-40 (1992); M.R. Bell and S. Archer, "L(+)-2-Tropinone", J. Amer. Chem. Soc., 82, pp. 4642-44 (1960)).

New York State Law Public Health Law Schedules Of Controlled Substances
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HSN codes for organic chemicals - HOW to Export …

All cocaine and ecgonine (and all salts, derivatives, and preparations from which cocaine or ecgonine may be synthesized or made) contained in such additional amounts of coca leaves imported under this subsection shall be destroyed under the supervision of an authorized representative of the Attorney General.