Diversity Oriented Synthesis: A Challenge for Synthetic Chemists
Wow, a lot of hate for this work here in the comments. I agree with Derek’s perspective though and it makes me (an organic chemistry PhD candidate) sad and kind of worried. Sad that this field that I love might one day be thought of the way I think about peptide coupling chemistry (Ech!). Worried that my job prospects might be highly limited in 20 years time.
This is clearly very good work and I think people need to understand that this is not the final product, but rather a proof of concept that, for the first time, shows that fully automated synthesis is entirely possible. Yes, the process is limited to sp2-sp2 (and primary sp3) coupling at the moment and we haven’t yet made an infinite catalog of BMIDA compounds, but these are only challenges that will eventually be overcome. The battle has only just begun, but it has already been won. Cheers to Burke and his students though, truly fantastic work.
Diversity-oriented synthesis; a challenge for ..
Prerequisites:EITHER General Microbiology (SBS758) OR Basic Biochemistry (SBS017) plus one Chemistry Year 1 option. Diversity of microbial metabolisms. Bacterial growth and replication, including organization and division of the chromosome, yield and responses to temperature and nutrient availability. Photolithotrophy, photoorganotrophy, chemilithotrophy and chemoorganotrophy. Fermentation and anaerobic respiration. Growth and extension metabolism of fungi. Nitrogen transformations by microorganisms in free-living and mutualistic settings. Microbiological standards in public health. Clean water processing and waste-water treatment. Practical work will cover prokaryote photosynthesis, bacterial fermentation, fungal digestion of wood and nitrogen transformations in sediments, and microbiological water quality. There will be a brief consideration of clean water processing and waste-water treatment.
The search for new drugs to treat a wide range of human ailments remain a great challenge to the pharmaceutical and biotechnology industries. Students will be given a perspective on the history of drug discovery to the present challenges in drug design. The medicinal chemistry content will provide students with an understanding of the complex biological and chemical problems that are involved in the design and synthesis of novel therapeutic agents. They will be given an in-depth analysis of the principles of identifying new compounds with the potential to be drugs, and their development for therapeutic use. Students will also be given an understanding of preclinical testing of drugs including the use of animal models for safety testing, intra and inter-species variations, detecting carcinogenicity in experimental systems and man, strategies of new initiatives in pharmaceutical development and risk assessment of pharmaceuticals. Introductory lectures will be followed by lectures in specialized areas of the subject given by experts in their field. In addition to formal lectures and interactive seminars, the course will provide tutorials with opportunities to critically-evaluate research papers. We will offer practical workshop sessions to reinforce the lectures.
Courses of Study | IIT Gandhinagar
Diversity-oriented synthesis (DOS) has been discussed here often and the benefits of employing fluorous tags and purification methods to the construction of such libraries has been effectively established. Among these are the solution phase nature of the chemistry, the general …