Role copper collagen synthesis | …

Red light alone maintains fibroblast activity and increased collagen synthesis

Vitamin C helps collagen synthesis and acts as antioxidant: 1

AB - Dietary copper deficiency induces alterations of connective tissue metabolism that are associated with lesions in cardiovascular and other organ systems. To determine the impact of copper deficiency on characteristics of collagen in porcine myocardium and cardiac valves, weaned pigs were fed diets with adequate or deficient levels of copper. Although dietary copper did not affect the concentration of collagen in either myocardium or bicuspid valves, the degree of collagen cross-linking, as assessed by the level of hydroxylysylpyridinoline, was lower in both tissues of copper-deficient pigs. Proportions of type III collagen were increased in the left ventricle and bicuspid valves of copper-deficient pigs. Copper deficiency induced extensive remodeling, however, of the collagen fraction of cardiac interstitium. Reduction in left ventricular collagen cross-linking may provide the stimulus for the development of cardiac hypertrophy, which characterizes severe copper deficiency, by increasing the compliance of the ventricular wall. The shift in the phenotypic profile of collagen that is associated with this cardiac hypertrophy indicates synthesis of new collagen, which could affect collagen cross-linking irrespective of copper status.

T1 - Copper deficiency alters collagen types and covalent cross-linking in swine myocardium and cardiac valves

Triggers collagen and elastin synthesis but less than copper …

VERY IMPORTANT! Many of the copper peptides mentioned here, including Super Cop, are entirely different forms of copper from the original GHK peptide. They are soy-based copper peptides, and a lot of people have terrible trouble with them. Some love them, but others get worse and even quite severe wrinkling. GHK Copper is the one that most people like and have no trouble with. This difference is very important!

While all tissue remodeling copper peptides may be similar, most information at this time is about skin repair and renewal.

I became quite excited when I first found out about copper peptides. It has been referred to as the most effective skin regeneration ingredient, even though it’s only been on the market since 1997. And then I became baffled. In all those ten years, there is a relative paucity of products containing copper peptides. Why should that be? Perhaps it turned out not to be so good after all. Or perhaps there are ghastly side effects.

As far as I can tell, copper peptides are effective and proven to be so. The reason why they aren't as common as, say, AHAs seems to be because there is a stranglehold on the patent. So much of a stranglehold that some products that claim to be based on copper peptides aren't really and will not work at all at improving skin texture. Here’s why:

The benefits of copper peptides for tissue regeneration were discovered by Dr. Loren Pickart in the 1970s. He found and patented a number of specific copper peptides (in particular, GHK copper peptides or GHK-Cu) that were effective in healing wounds and skin lesions as well as some gastrointestinal conditions. Pickart still controls these patents and, therefore, very few products contain the GHK copper peptide. An exception is Neutrogena, which has a deal with Pickart to include GHK in low doses. As you might have now guessed, one of the few ways to buy a potent and genuine product is from Pickart himself.

A peptide is a short chain of amino acid (protein is a long chain), while the presence of copper in living tissues has been known for more than 200 years and was popularized by those copper bracelets that Grandma wore to ward off rheumatism. But can copper peptides diminish wrinkles as well as they seem to heal scars?

Theoretically, it is possible since copper peptides promote the degradation of abnormally large cross-linked collagen (the one found in scars and, to a lesser degree, in wrinkles). They also stimulate the production of 'regular' collagen found in normal skin. In one small study of about 20 volunteers, copper peptides stimulated collagen production in the intact skin. In fact, in that study copper peptides produced a stronger stimulation of collagen synthesis than tretinoin (Retin A, Renova) or ascorbate (vitamin C).

A study performed upon 20 volunteers showed that after 30 days, the formation of procollagen, a precursor of collagen, increased 70% (shown by skin biopsy) compared with 50% formation from Vitamin C and 40% due to Tretinoin.

This all seems to promising that its worth going back to Dr Pickart (a maverick who doesn't believe that sun damage is the primary cause of wrinkles). He favors a two-step program: out with the old and in with the new. An exfoliant (mild hydroxy acids) is applied to the skin in the morning to slough off the old skin cells. The copper peptide is then used in the evening, to encourage the production of new, healthy skin cells.

Copper deficiency alters collagen types and covalent …

points out that studies have shown copper peptide promotes collagen and elastin production and also acts as an antioxidant. It also promotes production of . Clinical studies have found that copper peptides also remove damaged collagen and elastin from the skin and scar tissue because they activate the skin’s system responsible for those functions. Copper is the key mineral in lysyl oxidase, an enzyme that weaves together collagen and elastin.

Copper is an essential mineral for collagen synthesis

Copper peptides have an impressive clinical pedigree going back to the 1970s. They are proven wound healers, can help hair growth and have been in skin care products for past 20 years. Today, they are regarded as one of the most potent skin regeneration actives, and much more is understood about how they work and how we can get the most out of them as an anti-aging active for skin and hair. There are still a few urban myths persisting though, so here’s the truth about copper peptides.

Structure and synthesis of collagen in the human body

GHK-Cu treated rat wounds had a concentration dependent increase of dry weight, DNA, total protein, collagen, and glycosaminoglycan. The stimulation of collagen synthesis was twice that of noncollagen proteins.

stimulating the synthesis of collagen and ..

GHK-Cu stimulated collagen synthesis in cultured fibroblasts. The stimulation began between 10exp (-12) and 10exp (-11) M, maximized at 10exp (-9) M, and was independent of any change in cell number.