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A primary objective of the Townsend lab is to design new antibacterial and antibiofilm agents based on novel mechanisms of action. Currently, all antibiotics used in the clinic function by one of a limited number of mechanisms (e.g. inhibition of protein synthesis, DNA synthesis, cell-wall synthesis, and RNA transcription). We search human milk and understudied plants for novel molecules to fight a variety of bacterial based pathogens. Ideally, once a molecule is identified, we apply organic chemistry efforts to methodically optimize the scaffold.
Microwave Synthesis & Synthetic Chemistry | Anton …
While conventional heating works by means of a heated surface which in turn heats the reaction vessel content (Figure 3, a), microwave irradiation provides energy-efficient internal heating by direct coupling of microwave energy with dipoles and/or ions present in the reaction mixture (Figure 3, b).
In the early days of microwave synthesis, household microwave ovens were used in chemical laboratories. Although nowadays dedicated instrumentation is available, there are still chemists who use kitchen microwave ovens for scientific purposes. However, most major scientific journals no longer accept manuscripts wherein domestic ovens have been described as heating sources, since there are serious scientific and safety-related arguments to be made for using dedicated instrumentation.
Microwaves in Organic Synthesis
Microwave chemical synthesis has become a method of choice for chemists throughout so many industries. The benefits over the last 20 years make this a first choice for doing research. The technology allows synthesis to be done faster and cleaner with reduced solvent consumption as a “greener” process. Milestone’s synthesis product suite provides a number of options to meet research needs: high-throughput productivity, small-scale research, high-temperature and pressure parameters and larger-scale capabilities.
Some years ago microwave synthesis was ..
Imaginative organic chemists had figured out that there’s an advantage to using microwaves to rapidly and uniformly heat reaction mixtures to accelerate synthetic processes.
Sineo Microwave Chemistry Technology
Prof. Rajender S. Varma was born in India (Ph.D., Delhi University 1976). After postdoctoral research at Robert Robinson Laboratories, Liverpool, U.K., he was faculty member at Baylor College of Medicine and Sam Houston State University prior to joining the Sustainable Technology Division at the US Environmental Protection Agency in 1999. He has over 40 years of research experience in management of multidisciplinary technical programs ranging from natural products chemistry to development of more environmentally friendly synthetic methods using microwaves, ultrasound, etc. Lately, he is focused on greener approaches to assembly of nanomaterials and sustainable applications of magnetically retrievable nanocatalysts in benign media. He is a member of the editorial advisory board of several international journals, has published over 380 scientific papers, and has been awarded 12 US Patents.
[Lab 8] Microwave Synthesis - マイクロ波合成反応 - …
The microwave route provides a novel, fast, clean, and energy-efficient method for preparation of many inorganic solids. This review summarizes, with typical examples, the present understanding of the nature of the microwave-assisted synthesis. Microwave irradiation results in volumetric heating, and most indications show that there is a “nonthermal” effect, which makes microwave synthesis very fast and occur at temperatures lower than in conventional methods.
Microwave synthesis - SlideShare
It also reduces the need for solvents, thus it is eco-friendly. It has been exploited in a variety of organics synthesis including hetero cyclic, organ metallic, and combinatorial chemistry. Some of the reported advantages are rapid reactions under controlled temperature and pressure (especially in a closed system), higher purity products achieved due to short residence times at higher temperatures, and better yields at even very short residence