ChemiosmoticHypothesis of Oxidative Phosphorylation.
In prokaryotic cells, all the metabolic pathways occur in the cytoplasm, except for chemiosmosis and oxidative phosphorylation, which occur on the plasma membrane. Prokaryotic cells are capable of anaerobic respiration using alternative electron acceptors such as nitrate and sulfate, although they prefer oxygen as the terminal electron acceptor to drive chemiosmotic ATP synthesis. In the absence of any suitable electron acceptor, they use fermentation pathways.
Chemiosmotic hypothesis Edit Oxidative phosphorylation
In the 1960s, the ideas of cell function and electron transfer were generally known, but there were no specifics or mechanisms that had been discovered or theorized about at the time. Having electron transfer coupled to ATP synthesis through oxidative phosphorylation and photophosphorylation was unknown. Several hypotheses existed, but before Mitchell, most looked at a direct chemical interaction.
Prerequisites: Basic Biochemistry (SBS017). This module coves a range of topics: Membrane functions and subcellular organelles; lipid structures; membrane proteins; mobility in membranes and methods for its measurement; cell signalling.; membranes and cancer; endocytosis and exocytosis; protein import; building membranes; mitochondria and chloroplasts; oxidative phosphorylation; the chemiosmotic hypothesis; membrane transport; ion channels.