Green Synthesis of Cephalosporin by Timi Shiock on Prezi

Complete schematic view of the 1966 Cephalosporin C1's synthesis performed by Robert B. Woodward
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cephalosporin biosynthesis - QMUL

Synthesis of cephalosporin oligopeptides from 7β-amino-desacetoxycephalosporanic acid and hydrophobic amino acids is described. Their in vitro inhibitory activities against porcine pancreatic elastase, α-chymotrypsin and human immunodeficiency virus type 1 proteinase (HIV-1 PR) were tested by spectroscopic assays and against HIV-1 PR also by a HPLC assay. Up to 0.2 mM concentration they did not show any inhibition. However, using the HPLC method, they were found to be weak inhibitors of HIV-1 PR, with IC50 values in the millimolar range.

Synthesis and SAR of novel parenteral anti-pseudomonal cephalosporins: Discovery of ..
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Synthesis of Multiply Deuterated Cephalosporins

N2 - Synthesis of cephalosporin oligopeptides from 7β-amino-desacetoxycephalosporanic acid and hydrophobic amino acids is described. Their in vitro inhibitory activities against porcine pancreatic elastase, α-chymotrypsin and human immunodeficiency virus type 1 proteinase (HIV-1 PR) were tested by spectroscopic assays and against HIV-1 PR also by a HPLC assay. Up to 0.2 mM concentration they did not show any inhibition. However, using the HPLC method, they were found to be weak inhibitors of HIV-1 PR, with IC50 values in the millimolar range.

Cephalosporins disrupt the synthesis of the bacterial cell wall.
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The synthesis and the structure-activity relationships of 3-thiazoliomethyl cephalosporins are described. In a series of these parenteral compounds, 2-(2-aminothiazol-4-yl)-()-2-methoxyiminoacetamido group was found to be a favorable substituent for the C-7 position of the cephem nucleus. They showed potent antibacterial activity against both Gram-positive and Gram-negative bacteria including some β-lactamase producing species.

cephalosporins synthesis inhibitors Study Sets ..
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