Process of protein biosynthesis

The main stages of protein synthesis are transcription and translation.

Protein biosynthesis - Wikipedia

Steward O and Worley PF (2001) A cellular mechanism for targeting newly synthesized mRNAs to synaptic sites on dendrites. Proceedings of the National Academy of Sciences of the USA 98(13): 7062–7068.

Maffei L and Berardi N (2002) Protein synthesis in the visual cortex is needed for ocular dominance plasticity. Neuron 34(3): 328–331.

Protein Synthesis Flashcards | Quizlet

Casadio A, Martin KC, Giustetto M et al. (1999) A transient, neuron‐wide form of CREB‐mediated long‐term facilitation can be stabilized at specific synapses by local protein synthesis. Cell 99(2): 221–237.

Steward O and Schuman EM (2001) Protein synthesis at synaptic sites on dendrites. Annual Review of Neuroscience 24: 299–325.

Kasahara J, Fukunaga K and Miyamoto E. (2001) Activation of calcium/calmodulin‐dependent protein kinase IV in long term potentiation in the rat hippocampal CA1 region. Journal of Biological Chemistry 276(26): 24044–24050.

Alterations of neuronal protein synthesis in humans can cause a variety of behavioural, cognitive and memory deficits.


09/03/2017 · Protein synthesis is accomplished ..

Neurons are immensely complex cells whose morphology and physiology underpin our cognition. Achieving proper neuronal connections during development, as well as eliciting appropriate responses to environmental stimuli in the adult, requires precisely regulated protein synthesis. To meet these requirements, neurons have adapted regulatory mechanisms that act at every step in the process of producing functional proteins. Many of these mechanisms target messenger ribonucleic acid (mRNA)‐binding proteins and ribosomal subunits to regulate translational initiation. These mechanisms are especially concentrated at synapses, where they act to transform transient electrical signals into lasting functional modifications that are a basis for learning and memory. Misregulated synaptic protein synthesis contributes to several human cognitive changes including addiction, fragile X syndrome and autism.

Name the cell stucture that is the site of protein synthesis?

RNAs involved in protein biosynthesis
Information flow in the cell: DNA is transcribed to mRNA which is translated (decoded as) into Protein. Protein biosynthesis takes place in the ribosomes. A series of ribosomes (poly ribosome) can simultaneously translate the same eukaryotic mRNA molecule. tRNA brings specific amino acid to ribosome and mRNA carries the genetic information to protein. Codons that encode the same amino acid often differ only by their third base. The binding of the third base is less stringent than the other two. Because of this wobble, one tRNA can pair with multiple mRNA codons.

Name the site of protein synthesis inside a cell

Process of protein biosynthesis
There are signal sequences before the real coding sequence at the translation initiation sites. Amino acid activation is catalyzed by amino acyl-tRNA synthetase and couples it to its corresponding tRNA. Anti codon in tRNA molecule forms base pairs with the appropriate codon on the mRNA. In the initiation step, initiation factors are involved. Initiation factor is the protein that promotes the proper association of ribosomes with messenger RNA. In the elongation step, incorporation of an amino acid into a protein takes place. As a result, polypeptide chain is grown. Termination is the last stage in protein biosynthesis.

Which cytoplasmic organelles are the sites of protein synthesis?

Quality control and chaperones
If at all, a wrong amino acid is added, tRNA synthetase removes the incorrectly attached amino acid through hydrolytic editing. There are protein molecules called chaperones that catalyze the correct folding of other proteins within the cell. They also help in preventing aggregation. The hsp70 family of molecular chaperones helps in correct folding after synthesis.