Patent US5006528 - Carbostyril derivatives - Google …

Synthesis, characterization, and antimicrobial evaluation of carbostyril derivatives ..
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A novel carbostyril derivative and salt thereof represented by the ..

The interaction of cell bound immunoglobulins (Ig) with antigen and haptens leads to the release of mediators of immediate hypersensitivity from these stimulated cells. IgE appears to interact with a specific plasma membrane receptor on the target cell. Characterization of the cellular receptor for IgE is determined using rat peritoneal mast cells and rat basophilic leukemia cells and indicates that it has a molecular weight of 60,000. In carbuterol, a series of compounds of general structure substitute in the benzyl group are claimed to be 10 x 5 in potency as bronchodilators with higher bronchoselectivity. A series of mono and diesters of N-t-butylarterenol shows that the monoesters have a moderate degree of activity with rapid onset and two hours duration of action. Structure–activity relationships for a series of sympathomimetic arnines, having a carbostyril moiety, are discussed in this chapter. Detailed pharmacology, toxicology, pharmacokinetics, and metabolite patterns of clenbuterol in rat, rabbit, dog, and man are also discussed in the chapter. In clenbuterol, synthesis, structure activity relationships, and pharmacology of a series of bronchospasmolytic, 0-phenylethylaminoalkylxanthines are selected for clinical trial. Corricosreroids–beclomethasone dipropionate aerosol was used in the treatment of chronic asthma, particularly in children.

Synthesis, characterization, and antimicrobial evaluation of carbostyril derivatives of 1H-pyrazole
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Carbostyril 124 99% | Sigma-Aldrich

N2 - The interaction of cell bound immunoglobulins (Ig) with antigen and haptens leads to the release of mediators of immediate hypersensitivity from these stimulated cells. IgE appears to interact with a specific plasma membrane receptor on the target cell. Characterization of the cellular receptor for IgE is determined using rat peritoneal mast cells and rat basophilic leukemia cells and indicates that it has a molecular weight of 60,000. In carbuterol, a series of compounds of general structure substitute in the benzyl group are claimed to be 10 x 5 in potency as bronchodilators with higher bronchoselectivity. A series of mono and diesters of N-t-butylarterenol shows that the monoesters have a moderate degree of activity with rapid onset and two hours duration of action. Structure–activity relationships for a series of sympathomimetic arnines, having a carbostyril moiety, are discussed in this chapter. Detailed pharmacology, toxicology, pharmacokinetics, and metabolite patterns of clenbuterol in rat, rabbit, dog, and man are also discussed in the chapter. In clenbuterol, synthesis, structure activity relationships, and pharmacology of a series of bronchospasmolytic, 0-phenylethylaminoalkylxanthines are selected for clinical trial. Corricosreroids–beclomethasone dipropionate aerosol was used in the treatment of chronic asthma, particularly in children.

Now you can chat with who search for : synthesis of 4-methyl carbostyril from acetoacetanilide
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N2 - The synthesis, photophysical properties, and kinetic stability of a series of water-soluble, highly emissive Tb(III) and Eu(III) complexes featuring triethylenetetraamine hexaacetic acid (TTHA) and cyclohexyl triethylenetetraamine hexaacetic acid (cyTTHA) chelator scaffolds and carbostyril sensitizers are reported. The unique and modular design of the chelators gives rise to striking quantum yields of emission in aqueous solutions (up to 54%) as well as the characteristic lanthanides' photophysical properties (long excited-state lifetimes, large effective Stokes shifts, and narrow emission peaks). Furthermore, the preorganized chelators (L3, L4, and L6) bind metal within minutes at ambient temperature yet exhibit substantial resistance to transchelation in the presence of a challenge solution (EDTA, 1 mM). Moreover, the Eu(III) complex of L4 remains stably luminescent in HeLa cells over hours, demonstrating the suitability of these compounds for live-cell imaging applications. Representative chelators suitable for derivatization and protein bioconjugation were also prepared that were functionalized with clickable azide and alkyne moieties, biotin, and trimethoprim (TMP). With exceptional long-wavelength brightness, enhanced kinetic inertness, and an adaptable synthetic route, the reported lanthanide complexes are promising probes and labels for time-gated bioanalysis, biosensing, and optical microscopy.

Synthesis, characterization and biological activity of some new carbostyril bearing 1H-pyrazole moiety
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characterization, and antimicrobial evaluation of ..

AB - The synthesis, photophysical properties, and kinetic stability of a series of water-soluble, highly emissive Tb(III) and Eu(III) complexes featuring triethylenetetraamine hexaacetic acid (TTHA) and cyclohexyl triethylenetetraamine hexaacetic acid (cyTTHA) chelator scaffolds and carbostyril sensitizers are reported. The unique and modular design of the chelators gives rise to striking quantum yields of emission in aqueous solutions (up to 54%) as well as the characteristic lanthanides' photophysical properties (long excited-state lifetimes, large effective Stokes shifts, and narrow emission peaks). Furthermore, the preorganized chelators (L3, L4, and L6) bind metal within minutes at ambient temperature yet exhibit substantial resistance to transchelation in the presence of a challenge solution (EDTA, 1 mM). Moreover, the Eu(III) complex of L4 remains stably luminescent in HeLa cells over hours, demonstrating the suitability of these compounds for live-cell imaging applications. Representative chelators suitable for derivatization and protein bioconjugation were also prepared that were functionalized with clickable azide and alkyne moieties, biotin, and trimethoprim (TMP). With exceptional long-wavelength brightness, enhanced kinetic inertness, and an adaptable synthetic route, the reported lanthanide complexes are promising probes and labels for time-gated bioanalysis, biosensing, and optical microscopy.