Ester Synthesis and Reaction Problems - BrainMass

Ester synthesis and reaction problems are solved and explained

Alcohol synthesis by 1,2-addition - Organic chemistry

As stated in the syllabus, the “point” of organic chemistry is synthesis, the construction of more complex molecules from simpler ones. By the end of the semester, you will have to solve synthesis problems in which you put together a sequence of several reactions to convert a starting molecule into a product molecule or product molecules. How do you study to prepare yourself for these problems? I believe the best way to review/learn organic chemistry reactions is through the creation of a so-called “roadmap”.

Examples of organic synthesis reactions related to topics ..

Terminal alkyne synthesis by C-C coupling


By the time you have completed this task for all the reactions we learn, you should be struck by how alkenes (aka Austin) really is at the center of the chemistry you learned in 320M/328M. That is, alkenes have the most arrows pointing toward them and away from them. You should now be ready to study for synthesis. For example, you should be able to see that if you were asked to synthesize an alkene from a corresponding alkane, you cannot do it directly. Rather, you would break it into two steps (alkane to alkyl halide using X and light or heat, followed by an E2 elimination of the alkyl halide using base such as KOtBu making sure to follow Zaitsev's rule). I call this a roadmap, because synthesis comes down to moving from one “location” (i.e. functional group) on the roadmap, to a different location, and the arrows (i.e. “roads”) tell you how you must travel. For 320M/328M, "I-35" is the most often traveled route in synthesis problems!

The Mighion group drives to utilize chemical synthesis and catalysis to solve structural and biological problems

I recommend you view the map as being roughly analogous to the state of Texas, with the I-35 corridor represented by alkanes (like San Antonio in the south), followed by alkyl halides (San Marcos), alkenes (Austin), vicinal or geminal dihalides (Waco) and alkynes (Dallas). You will find that as you convert different functional groups in synthesis problems, you will often travel along this path. Even more, you will notice that the alkenes, aka Austin, is the most versatile functional group covered in 320M/328M and it is the center of the "action", as is Austin in real life, of course. Most syntheses involve alkenes in one step or another (just like Texans generally find some reason to go through Austin whenever traveling within the state).

Organic Chemistry Oxidation and Reductions Reactions, Mechanisms, Reagents and more. Redox for alkenes, alkynes, alcohols, carbonyl compounds, nitriles …