Identification of cancer stem cells in brain tumors

Glioblastoma stem cells and the vascular niche

Cancer stem cells and tumor metastasis (Review)

Yao XH, Ping YF, Chen JH, Xu CP, Chen DL,Zhang R, Wang JM and Bian XW: Glioblastoma stem cells producevascular endothelial growth factor by activation of a G-proteincoupled formylpeptide receptor FPR. J Pathol. 215:369–376. 2008. : :

9. Croce CM, Calin GA. MiRNAs, cancer, and stem cell division. Cell. 2005; 122:6-7.

The cancer stem cell (CSC) hypothesis ..

Li () hypothesized that a single cancercell can be considered a CSC as long as it can: a) develop into atumor and b) its filial generation can inherit its biologicalfeatures. They cultured CD133 colorectal cancermonoplast cells and analyzed the invasive andmetastatic capabilities of CD133 single cell-derivedprogenies (SCPs) in a nude mouse model. They found thatCD133 SCPs were more likely to produced tumors afternude mice transplantation compared with CD133 SCPs, andthat CD133 cells were heterogeneous in invasion andmetastasis and . They concluded thatcolorectal CSCs constitute a diverse subpopulation.

More of Ed's Notes: Define the following terms and use them appropriately: Recognize the ways in which the growth properties of cancer cells differ from normal.

Testing the cancer stem cell hypothesis in melanoma: …

33. Hwang-Verslues WW, Chang PH, Wei PC, Yang CY, Huang CK, Kuo WH et al. MiR-495 is upregulated by E12/E47 in breast cancer stem cells, and promotes oncogenesis and hypoxia resistance via downregulation of E-cadherin and REDD1. Oncogene. 2011; 30 (21): 2463-74.

Chemotherapy curable malignancies and cancer stem …

It is believed that tumor metastasis is a complexmultistep process, characterized by local invasion followed byintravasation of cancer cells into blood and lymphatic vessels(). The intrinsic properties ofthe tumor itself and the tumor microenvironment are likely to bethe main triggers that determine the ability of cancer cells tometastasize ().

In this review we will examine the cancer stem cell/cancer ..

31. Li R, You N, Wang X, Dou K. MicroRNAs involved in neoplastic transformation of liver cancer stem cells. J Exp Clin Cancer Res. 2010; 29: 169.

Reviews - Cancer Stem Cell News

The ability of CSCs to participate in thedevelopment of endothelium directly contributes to understanding ofthe mechanisms of tumorigenesis and development. It challengestraditional theory on cancer and anti-angiogenesis therapy andemphasizes the potential of tumor lymphatic metastasis-resistanttherapy.

01/09/2005 · The Cancer Stem Cell Hypothesis

30. Ji J, Yamashita T, Budhu A, Forgues M, Jia HL, Li C et al. Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells. Hepatology. 2009; 50: 2047-8.

The Stem Cell Theory of Cancer | Ludwig Center | …

Limitations of anti-angiogenic therapy have beenreported (,). Although preclinical and clinicalstudies have established that anti-angiogenic therapies haveantitumoral effects and survival benefits, there are studiesshowing that tumor cells can develop multiple mechanisms ofresistance, which can increase tumor invasion and distantmetastasis. A more significant therapeutic strategy could targetboth blood and lymphatic vessels to maximize anti-tumor andanti-metastasis effects.