Synthesis of Gold Nanotriangles and Silver Nanoparticles Using ..
Three parameters were varied to optimize tumor targeting: the shape of the nanoparticle, the type of the targeting ligand, and the nature of the molecular linker. Two types of surface linkers were used to attach the targeting groups to the magnetic NWs or NSs. A short hydrocarbon places the targeting peptide (either F3 or CREKA, green lines) in close proximity to the dextran-coated nanostructure. A 5 kDa PEG linker places the targeting peptide further from the surface. The number of targeting groups per NW was varied to maximize the circulation time and optimize the tumor-targeting efficiency. These linker chemistries were tested on magnetic NSs. The NWs consisted of several NS cores linked together in a chain. Reproduced with permission from ref. .
Biochemical Synthesis of Ag/AgCl Nanoparticles for …
23. Kim BH, Lee N, Kim H, Am K, Park YI, Choi Y, Shin K, Lee Y, Kwon SG, Na HB, Park J-G, Ahn T-Y, Kim Y-W, Moon WK, Choi SH, Hyeon T. Large-scale synthesis of uniform and extremely small-sized iron oxide nanoparticles for high-resolution 1 magnetic resonance imaging contrast agents. 2011;133:12624-31
(A) Schematic representation of the binding of biotinylated gold nanoparticles to avidinylated UCNPs. Photographs: (a) colorless suspension of UCNP under visible light; (b) UCNPs with green luminescence under 980-nm laser excitation; (c) adding red Au-NPs under visible light. (B) Luminescence of the UCNPs (photo-excited at 980 nm) after addition of varying concentrations of biotinylated gold NPs. Adapted from reference .
the use of plants for nanoparticles synthesis ..
20. Shankar SS, Rai A, Ahmad A, Sastry M. Controlling the Optical Properties of Lemongrass Extract Synthesized Gold Nanotriangles and Potential Application in Infrared-Absorbing Optical Coatings. 2005;17:566-72
report of bio-synthesized silver nanoparticles ..
Ruoslahti . described self-amplifying tumor homing nanoparticles . The system was based on a CREKA peptide that not only recognizes clotted plasma proteins around tumor vessel walls or tumor stroma but also induces localized tumor clotting [-]. Fluorescein-labeled peptides, including the sulfhydryl group of the single cysteine residue, were coupled to amino dextran-coated iron oxide nanoparticles (CREKA-SPIO), and nanoparticles with at least 8,000 peptide molecules per particle were used for experiments. To reduce reticuloendothelial system (RES) uptake, a major obstacle to the homing of the nanoparticles, chelated Ni2+-liposome or liposomes as potential decoy particles were introduced prior to CREKA-SPIO injection. CREKA-SPIO treatment after pretreatment with the decoy particles displayed primary localization in the tumor vessels, and fewer particles were seen in the liver. The tumor-targeted nanoparticles were distributed along a meshwork in the clots, presumably formed by fibrin, suggesting that the nanoparticles infiltrated the depths of the clots. The tumor magnetization was quantitatively analyzed using a superconducting quantum interference device (SQUID), revealing that heparin injection prior to injection of CREKA-SPIO reduced the tumor accumulation of nanoparticles by >50% by eliminating intravascular clotting, although the treatment series did not considerably reduce the number of vessels. Thus, binding of CREKA-SPIO to tumor vessels did not require clotting activity, but intravascular clotting attracted more nanoparticles to the tumor, suggesting that tumor targeting was amplified.
Extracellular synthesis of silver nanoparticles ..
106. Jayapaul J, Hodenius M, Arns S, Lederle W, Lammers T, Comba P. . FMN-coated fluorescent iron oxide nanoparticles for RCP-mediated targeting and labeling of metabolically active cancer and endothelial cells. 2011;32:5863-71