BT - Organic Synthesis Using Biocatalysis

Recent Developments in Chemical Synthesis with Biocatalysts in Ionic Liquids.
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Biocatalysis and Biotransformation: Vol 36, No 2

For example, compound libraries rarely contain complex biomolecules such as carbohydrates with high levels of functionality, stereochemistry, and hydrophilicity.

"Recent Developments in Chemical Synthesis with Biocatalysts in Ionic Liquids." Molecules 20, no.
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Comprehensive Organic Synthesis - 2nd Edition

The Organic Chemistry and Chemical Biology section is engaged in a variety of research activities that are underpinned by organic synthesis. Research activities cover a broad range of topics from the development of new reaction methodologies and catalysts, target asymmetric synthesis of molecules with profound biological activity, through to peptide, protein and DNA chemistry, radiochemistry and molecule imaging, single molecule detection, mass spectrometry, bionanotechnology, biocatalysis, chemical genetics and directed evolution. In much of this work interactions with biology and medicine is vital and a number of exciting projects are developing new therapeutics for treatment of a variety of diseases including infection, cancer and cardiovascular disease. Activities in the areas of Chemical Biology and Medicinal Chemistry are coordinated through the .

Organic synthetic procedures to prepare a compound in a target‐oriented synthesis can damage other functional parts of the molecule.
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Furthermore the evolution of enzymes by means of DNA-shuffling is explored in collaboration with an industrial partner to search for reaction-designed biocatalysts.

Organometallic Chemistry
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in organic synthesis, biocatalysis for ..

The technique of using enzymes to mediate organic synthesis is widely endorsed due to their high selectivity and specificity, which ensures a more satisfactory yield and purity of the transformed products. Furthermore, by the use of protein engineering, the biocatalysis can be made even more efficient by having the enzyme customized to fit a specific need.

Duloxetine: Refining its Chemical Synthesis with Biocatalysis

When utilizing isolated enzymes for organic synthesis, the typical approach is to keep the enzymes immobilized on the surface of an insoluble material. This is preferred to using soluble enzymes due to both technical and economic benefits. The immobilization will allow for easier recycling, manipulation and separation of the enzyme, as well as an increase in its thermal and operational stability. Additionally, immobilization of the enzyme will ensure minimized protein contamination during the experimental procedure, and improved control over the overall reaction process.

Biocatalysis-in-Organic-Synthesis | EduRev

Using biocatalysts for chemical manufacturing is a highly developed and applied science, used widely for production and processing of pharmaceuticals and food items. Both enzymes and whole cells can be used to catalyze organic reactions, with the most general example of biocatalysis being the yeast-mediated transformation of sugars into alcohols, acids or gases. However, the most frequently employed group of biocatalysts is lipases. These enzymes are very versatile, facilitating the hydrolysis of lipids into fatty acids as well as the synthesis of esters and amides. Areas of lipase-catalyzed reactions include food processing, synthesis of fine chemicals and production of biofuel. Other regularly used enzymatic biocatalysts are proteases, cellulases and amylases, used for the hydrolysis of proteins, cellulose and starch, respectively.

In organic chemistry, the term organocatalysis ..

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