(2002), Analytical Methods for the ..

(2002), Analytical Methods for the Monitoring of Solid Phase Organic Synthesis.

Analytical methods for solid phase synthesis - …

Direct single bead FTIR analysis is a simple, sensitive, fast andhighly reliable method. It offers a way of monitoring reactions on solid support withoutstopping them or cleaving product from the resin and often provides information that wouldbe hard to obtain in any other way. IR peak shift and peak area changes can be used toobserve and quantitate intermediates in SPOS. Single bead FTIR can also providequantitative and kinetic information. Therefore, it is an effective analytical tool in theprocess of transferring solution-phase reactions to solid phase and optimizing SPOSreactions.

ChemInform Abstract: Analytical Methods for the Monitoring of Solid Phase Organic Synthesis

Analytical methods for solid phase synthesis

AB - The area of solid-phase synthesis has witnessed exponential growth in the last fifteen years, but difficulties associated with the monitoring aid analysis of resin-bound reactions and products have been apparent due to a limited number of analytical methods available. With the substrate tethered to an insoluble support traditional chromatographic monitoring is only possible after cleavage. In order to address this 'analytical bottleneck' Geysen, in 1996 elaborated Merrifield's initial dual linker strategy by incorporating an encoding system between two in-line linkers. These analytical construct resins represented a new approach for both the quality control of solid-phase combinatorial libraries and for the development of new synthetic sequences on solid-support. This review will summarize the development and application of analytical construct resins focusing on recent applications of the technology.

Methods for obtaining spectra of organic compounds bound to polymer supports for solid-phase synthesis are compared

N2 - The area of solid-phase synthesis has witnessed exponential growth in the last fifteen years, but difficulties associated with the monitoring aid analysis of resin-bound reactions and products have been apparent due to a limited number of analytical methods available. With the substrate tethered to an insoluble support traditional chromatographic monitoring is only possible after cleavage. In order to address this 'analytical bottleneck' Geysen, in 1996 elaborated Merrifield's initial dual linker strategy by incorporating an encoding system between two in-line linkers. These analytical construct resins represented a new approach for both the quality control of solid-phase combinatorial libraries and for the development of new synthetic sequences on solid-support. This review will summarize the development and application of analytical construct resins focusing on recent applications of the technology.

Methods for Combinatorial Organic Synthesis: The Use of Fast 13C NMR Analysis for Gel Phase Reaction Monitoring