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It also explains the mutually exclusive distribution of mitochondria and mitochondrion-related organelles, and the independent evolution of mitochondrion-related organelles in a range of unrelated eukaryotic lineages, whether or not they are related to known mitochondrial groups.The second proposal is less parsimonious and although it might help to explain the presence and phylogenetic affinities of the anaerobic enzymes hydrogenase and pyruvate:ferredoxin oxidoreductase in hydrogenosomes, it does not account for the multiple independent origins of mitochondrion-related organelles in unrelated eukaryotic lineages ().

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