DNA-encoded solid-phase synthesis

T1 - Regio- and stereo-controlled synthesis of [24,30-14C]-labeled-2,3-Epoxysqualene

solid-phase synthesis positive control

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CONCULSION: A close examination of in vitro antibacterial and antifungal profile of variously substituted novel 3- (5- substituted phenyl- 1, 3, 4-Oxadiazol- 2- yl) pyridines against tested bacterial and fungal strains provide a better structure-activity correlate which is summarized above. Amino and nitro group substituted oxadiazole derivatives showed eliciting inhibition of all bacteria and poor antifungal activities of these two compounds against Candida albicans. All the synthesized derivatives exhibited good antibacterial activity against Bacillus subtilis and Staphylococcus aureus and comparatively poor activity against Klbesiella species and Escherichia coli. Compounds IVa, IVb and IVe showed poor antifungal activity against Candida albicans and compounds IVc and IVd showed no sigfinicant antifungal activity.

Prof. Houk investigates  important in the synthesis of polymers, alkaloids,and steroids.

A series of 3- (5- substituted phenyl- 1, 3, 4- Oxadiazol- 2- yl) pyridines was designed, synthesized and characterized for evaluation of potential antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Klebsiella species and antifungal activity against Candida albicans. Structure-activity relationship led to the conculsion that compound IVb, and IVe exhibited good antibacterial activity against Bacillus subtilis and Staphylococcus aureus and comparatively poor activity against Klbesiella species and Escherichia coli. Compound C exhibited antibacterial activity against Staphylococcus aureus and very poor activity against rest of organism. Compounds IVa, IVb and IVe showed poor antifungal activity against Candida albicans and compounds IVc and IVd showed no significant antifungal activity. The interesting antimicrobial profile of compound IVb and IVe led us to select this derivative for further development. Present research our expected compounds were given below.

Scheme for Synthesis Of Schiff’s Base:

Two Position Synthesis of 4-bar-linkage-mechanism - …

CONCLUSION:This research work includes chemistry of Schiff bases which have been synthesized using different aromatic aldehydes and study of their biological activity.

Four Bar Synthesis for 3 Known Coupler Positions ..


four bar linkage synthesis - YouTube

RESULT AND DISCUSSIONS: Physical characteristic parameter of final synthesised compounds were the synthesised compounds are produce in good yields described in Table 3.

3. Graphical Synthesis | Kinematics | Mechanics

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